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Hirudin
| Brand Name | PIONEER |
| Product Name | Hirudin |
| CAS# | 113274-56-9 |
| Odour | Characteristic |
| Particie Size | 100% pass 80 mesh |
| Molecular Weight | 1468.52 |
| Molecular Formula | C66H93N13O25 |
Shelf Life | Two years |
Product description: Hirudin is the most significant active constituents, is extracted from leech and its salivary glands, and is a kind of small molecule protein (polypeptide) which comprised of 65-66 amino acid.
Function:
1) Health products (additive)
2) The cosmetics (additive)
3) Drugs (additive)
Name:Hirudin
CAS:113274-56-9
Molecular Formula: C66H93N13O25
Molecular Weight: 1468.52
Effects: A key event in the final stages of blood coagulation is the conversion of fibrinogen into fibrin by the serine protease enzyme thrombin.Thrombin is produced from prothrombin, by the action of an enzyme, prothrombinase, in the final states of coagulation. Fibrin is then cross linked by factor XIII to form a blood clot. The principal inhibitor of thrombin in normal blood circulation is antithrombin III. Similar to antithrombin III, the anticoagulatant activity of hirudin is based on its ability to inhibit the pro-coagulant activity of thrombin.
Hirudin is the most potent natural inhibitor of thrombin. Unlike antithrombin III hirudin binds to and inhibits only the activity of thrombin forms with a specific activity on fibrinogen. Therefore, hirudin prevents or dissolves the formation of clots and thrombi (i.e. it has a thrombolytic activity), and has therapeutic value in blood coagulation disorders, in the treatment of skin hematomas and of superficial varicose veins, either as an injectable or a topical application cream. In some aspects, hirudin has advantages over more commonly used anticoagulants and thrombolytics, such as heparin, as it does not interfere with the biological activity of other serum proteins and can also act on complexed thrombin.
Founded in 2003 as a professional international pharmaceutical corporation, headquartered in Xi'an (China), Shaanxi Pioneer Biotech Co., Ltd. is a leading producer of standardized herbal extracts, natural active ingredients and APIs for pharmaceutical, health food and cosmetic industries.
Annually, more than 3,000 tons of a wide range of herbal extracts and natural active substances are extracted at the Shaanxi Pioneer Biotech Co., Ltd. manufacturing plant near Xi'an, China. These extracts are in compliance with worldwide GMP,HACCP norms, international Pharmacopoeias, and international regulations. The botanical raw materials are subject to strict selection and inspection, and extracts are manufactured according to methods developed by Pioneer. They include inspections to guarantee a high quality standard from both analytico-chemical and therapeutic points of view, and take into consideration the state of art in different fields: research and development, analyses, processes and machinery, therapeutic applications on a scientific basis.
Quick Details
Type: | Herbal Extract | Variety: | leech extract powder | Form: | Powder |
Part: | Other | Extraction Type: | Solvent Extraction | Packaging: | Drum, Aluminium foil bag |
Place of Origin: | China (Mainland) | Grade: | AAA | Brand Name: | PIONEER |
Appearance: | white fine powder | Specification: | 98% |
Packaging & Delivery
Packaging Detail: | 1kg/one plastic bag and aluminium foil bag outside, 25kg/Fiber Drums with double plastic bags inside. |
Delivery Detail: | Within 3 days after receiving payment. |
Specifications
leech extract powder
CAS: 113274-56-9
Molecular formula: C66H93N13O25
Formulation: white fine powder
Function
A,Hirudin is a naturally occurring peptide in the salivary glands of medicinal leeches (Hirudo medicinalis) that has a blood anticoagulant property. This is fundamental for the leeches’ alimentary habit of hematophagy, since it keeps the blood flowing after the initial phlebotomy performed by the worm on the host’s skin
B,Thrombin is produced from prothrombin, by the action of an enzyme, prothrombinase, in the final states of coagulation. Fibrin is then cross linked by factor XIII to form a blood clot. The principal inhibitor of thrombin in normal blood circulation is antithrombin III.
C,Similar to antithrombin III, the anticoagulatant activity of hirudin is based on its ability to inhibit the pro-coagulant activity of thrombin.Hirudin is the most potent natural inhibitor of thrombin. Unlike antithrombin III hirudin binds to and inhibits only the activity of thrombin forms with a specific activity against fibrinogen.
D,Therefore, hirudin prevents or dissolves the formation of clots and thrombi (i.e. it has a thrombolytic activity), and has therapeutic value in blood coagulation disorders, in the treatment of skin hematomas and of superficial varicose veins, either as an injectable or a topical application cream. In some aspects, hirudin has advantages over more commonly used anticoagulants and thrombolytics, such as heparin, as it does not interfere with the biological activity of other serum proteins and can also act on complexed thrombin.
Package&Storage
Package: 1kg/one plastic bag and aluminium foil bag outside, 25kg/Fiber Drums with double plastic bags inside.Storage: 2 years properly stored.
Item | Test Result |
Appearance | Light Yellow Powder |
Odor | characteristic fishy smell of the leech |
Particle Size | 120 mesh |
Loss on Drying | MAX 2.0% |
Total Plate Count | MAX 1000cfu/g |
Yeast & Molds | MAX 100cfu/g |
E,coli | Negativce |
Salmonella | Negativce |
Packing and Storage | Pack in paper-drums outside. one aluminium bag and two plastic-bags inside. Net Weight: 5kgs/Aluminium bag. Store in a well-closed container away from moisture. Keep away from strong light and heat |
Expiration Date | Jan.20, 2015 |
Leech powder in bulk stock, worldwide fast delivery