Ads by Google
1.Discovery of HA:In 1934, Karl Meyer isolated a formerly unknown glycosaminoglycan from the vitreous humor of the bovine eye. It differed from any of the other previously discovered glycosamlnoglycans in that it did not contain sulffur. With its distinctive structure, its function within the body was unique. It was named hyaluronan and further scientific study ensued. At the time of its discovery, the new compound took on two names: hyaluronan when referring to its endogenous synthesis and hyaluronic acid when discussing research conducted outside of the body-huma or animal. Today hyaluronan is comonly referred to as hyaluronic acid, regardless of the context in which it is spoken.2.Structure of HA:Hyaluronic Acid is linear, unbranched, high molecular weight polysaccharides containing a repeating disaccharide unit (D-glucuronic acid and N-acetyl glucosamine). HA, in its natural state, weighs about from 0.5-3.0 million daltons. Its weight lends itself to high viscosity and excellent lubrication within the body. The other glycosaminoglcans in the body include chondroitin sulfate, keratan sulfate, dermatan sulfate, and heparin sulfate.3. Distribution of HA:HA widely consists in the extracelluar spaces of animal tissue. Almost kinds of animal tissue contain the different quantity of HA. Today Hyaluronic Acid has been found from skin, cockcomb, brain, vitreum, connective tissue, umbilical cord, human serum, articular fluid, gristle, human urine, cock embryo, oocyte, artery and vein etc.
HA production typically increases during processes such as wound healing, cell migration, and blood vessel creation. During wound healing, HA is thought to open the provisional fibrin matrix in the early stages, allowing for new cells to fill the wound and remodel the tissues. Although HA is non-adhesive to cells alone, several cell surface receptors for HA have been identified on several cell types and are postulated to have several biological effects. The most common of these receptors is called CD44, which is present on vascular endothelial cells where it is thought to be necessary for building blood vessels and the protective insulating myelin layer on neurons in the nervous system. The blood vessel building properties of HA further explains its importance in wound healing. After all, it is the blood vessels that serve as the highways and byways for nutrient delivery for the repair of damaged tissues. Without the ability for cellular building blocks to be delivered all the supplementation in the world won’t get the job done as the trillion cells that comprise your body seek to maintain and regain their optimal integrity and function.
Since collagen makes up 70 percent of the dry weight of the dermis layer of the skin, it’s no surprise that collagen is essential for wound healing. Hyaluronidase breaks down both HA and collagen. Collagen is also broken down by the enzyme collagenase. As we age, our fibroblasts produce more collagenase than young fibroblasts, breaking down the body’s stores of collagen faster.
Hyaluronic acid / HA Topical Grade