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Pravastatin sodium USP
Pravastatin sodium USP
Supplier Info
[China Supplier]
Contact Person : Mr. Xu George
Tel : 86-573-84291300
Fax : 86-573-84291301
Product Detail
1. High quality 2. Competitive price 3. Prompt delivery by DHL, Fedex, TNT 4. Port, Shanghai, China

Description: Pravastatin is the HMG-CoA reductase inhibitors, which reduce cholesterol biosynthesis. These agents are competitive inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, the enzyme catalyzing the early rate-limiting step in cholesterol biosynthesis, conversion of HMG-CoA to mevalonate.

Action: 1. decresed cholesterol synthesis.

2. decresed cholesterol content of hepatic cells.

3. increased LDL-receptor synthesis, enhaced LDL clearance

4. increased HDL-cholesterol 5-15%, decresed triglyceride 7-30% and LDL-cholesterol 20-35%.

Pharmacokinetics: average absorption of pravastatin 34%; bioavailability 17%; time to peak conc 1~1.5 hrs; elimination half life 1.5~2 hrs; fist pass extraction in the liver (extraction ratio 0.66); protein binding 55%.

Pravastatin sodium USP

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