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1. Product Name: Calcium Dobesilate Monohydrate
2. CAS RN: 20123-80-2
3. Structural Formula:
4. Molecular formula & Molecular weight: C12H10CaO10S2·H2O 436.4
5. Characters: A white or almost white, hygroscopic powder, very soluble in water, freely soluble in ethanol, very slightly soluble in 2-propanol, practically insoluble in methylene chloride.
6. Quality standard: EP6.0/BP2005.
Identification | The specific absorbance at the maximum at 301 nm is 174 to 181. |
A blue colour and a precipitate are immediately produced. | |
Solution S gives reaction of calcium | |
Appearance of solution | Solution S is clear and colorless |
pH | 4.5 to 6.0 |
Hydroquinone | Not more than 0.1% |
Heavy metals | Not more than 10ppm |
Iron | Not more than 10ppm |
Water | 4.0% to 6.0% |
Assay | Calcium dobesilate monohydrate contains not less than 99.0 per cent and not more than the equivalent of 102.0 per cent of calcium di(2,5-dihydroxybenzenesulphonate), calculated with reference to the anhydrous substance. |
7. Usage:
1). Treatment of ischemic vascular disease: diabetic microangiopathy - retinopathy and glomerulosclerosis (Kimmelstiel-Wilson syndrome). Non diabetic microangiopathy - microangiopathy which are destined for idiopathic or long-time usage of coumarin derivatives, cell growth inhibitor;cytostatic preparation, oral contraceptive or other drugs; microcirculatory disturbance of relating to chronic organic disease( such as hypertension, arteriosclerosis and hepatic cirrhosis).
2). Treatment of varicose veins syndrome: primary varicose veins - pain, lower limb heaviness, muscle cramp, abnormal sensation, acrocyanosis, pigmentary purpuric dermatosis. Varicosity status - chronic venous insufficiency, phlebitis and superficial thrombogenicity phlebitis, pts postthrombotic syndrome, varicose ulcer, gestational varicosity.
3). Treatment of concomitant venous insufficiency of microcirculatory disturbance: haemorrhoids syndrome. varicose veins
4). Adjuvant therapy of vein strip and endoscopic injection sclerotherapy: prevent postcholecystestomy syndrome, hydroncu and Tissue infiltration.
8. Storage: It stored in sealed containers, cool and dry place.
9. Packing: Paper bucket, 25kg/package.
10. Shelf life: Tentative 2 years.
Calcium Dobesilate Monohydrate(drug for ischemic vascular disease varicose veins)