drug for ischemic vascular disease, varicose veins Characters: Itaas a white or almost white crystal powder, odorless, bitter Calcium Dobesilate Monohydrate

1. CAS RN: 20123-80-2

2. Structural Formula:  

                                      

3. Molecular formula & Molecular weight: C12H10CaO10S2·H2O  436.4   

4. Characters: It’s a white or almost white crystal powder, odorless, bitter taste, easily deteriorate by light, has the water absorbability. It’s very freely soluble in water, freely soluble in ethanol or acetone., hardly soluble in chloroform or aether.

5. Quality standard: EP5.0/BP2005.

6. Usage:

1). Treatment of ischemic vascular : diabetic microangiopathy - retinopathy and glomerulosclerosis (Kimmelstiel-Wilson syndrome). Non diabetic microangiopathy - microangiopathy which are destined for idiopathic or long-time usage of coumarin derivatives, cell growth inhibitor;cytostatic preparation, oral contraceptive or other drugs; microcirculatory disturbance of relating to chronic organic disease( such as hypertension, arteriosclerosis and hepatic cirrhosis).

2). Treatment of varicose veins syndrome: primary varicose veins  pain, lower limb heaviness, muscle cramp, abnormal sensation, acrocyanosis, pigmentary purpuric dermatosis. Varicosity status - chronic venous insufficiency, phlebitis and superficial thrombogenicity phlebitis, pts postthrombotic syndrome, varicose ulcer, gestational varicosity.

3). Treatment of concomitant venous insufficiency of microcirculatory disturbance: haemorrhoids syndrome.  varicose veins

4). Adjuvant therapy of vein strip and endoscopic injection sclerotherapy: prevent postcholecystestomy syndrome, hydroncu and Tissue infiltration.

7. Storage: It stored in sealed containers, cool and dry place.

8. Shelf life: Tentative 2 years.

Calcium Dobesilate Monohydrate