Almost-white or light yellow unfixed powder,smell-less,hygroscopic freely. Optical isomer: 0.500% Assay: 98.5%

Pemetrexed Disodium CAS 150399-23-8

Molecular Formula: C20H19N5Na2O6

Molecular Weight: 471.37

........................................................................CAS Registry Number: 357166-30-4Character: white or white crystalline powder; odorless,tasteless, easily absorb water;

Solubility: freely soluble In Water,practically insoluble In chloroform, slightly soluable in Methanol;

 Specific Rotation:+10°~16°;

Identification: (1)flame reaction with sodium salt;(2)The reaction time in the chromatogram of the assay preparation coorresponds to that in the chromatogram of the standard preparation, as obtained in the assay;(3)IR: should conform to the standard;PH: 6.5-8.0;Clear and color of solution:should conform to standard;

Related substances:Individual impurity: <0.5%;tatal impurity: <1.0%; Ethanol, Methylene Chloride, ethyl acetate, N,N-dimethylformamide dimethyl acetal: Ethanol < 0.5%, Methylene Chloride<0.06%, ethyl acetate< 0.5%,N,N-dimethylformamide dimethyl acetal< 0.088%;

Assay:not less than 98.5%(on andydrous basid).............................................................................................................................

Pemetrexed disodium