... FLT3 ,PDGFR, and KIT with IC50 values of 95-122 ng/mL, but had no significant effect against a broad range ... FLT3-ITD auto-phosphorylation with IC50 values of 6-17 ng/ml. Tandutinib also inhibited in vitro proliferation of human leukemia ... containing FLT3-ITD mutations with IC50 values of approximately 6 ng/mL. [2]Tandutinib has a very limited spectrum of activity ...