... kinase inhibitor that targets KIT. The stem cell factor (SCF) receptor, KIT, also called CD117 or c-KIT ... KIT regulate erythropoiesis, lymphopoiesis, megakaryopoiesis, gametogenesis, melanogenesis, with SCF also serving as an important growth factor. gain-of-function ... cells expressing human wildtype KIT, masitinib dose-dependently inhibited SCF-induced cell proliferation with an IC50 of 150 nM ...