Product Name

Amantadine Hydrochloride

Classification

Antibiotic and Antimicrobial Agents

CAS NO.

665-66-7

EINECS No

211-560-2

Specs

≥99% (GC)

Physical and

chemical properties

Molecular Formula: C10H17N.HCl

Molecular weight: 187.71

Structural Formula:

Description: white crystal powder, odourless; soluble in water, ethanol and chloroform, unsoluble in the acetone.

Application

Use to make intermediate of antivirus mediclne for treating A2 type flu virus, Has antipyretic effect in the clinical pharmacology;Amend fremitus and anaesthesia of Parkinson's disease symptom.

Package

25kg/drum

Storage

Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Avoid to contact water or moisture during Storing&Transporting.

Items

SPECIFICATION

RESULT

Appearance

Yellow crystalline powder

Complies

Identification

As Stipulated

Complies

Identification A

HPLC

Complies

Identification B

Sulphuric acid reaction a yellow colour develops

Complies

Identification C

It gives reaction of chlorides

Complies

Heavy Metal

≤50ppm

<50ppm

pH

2.0-3.0

2.5

Related substance

a) 6-epidoxycycline≤2.0%

1.8%

b) metacycline≤2.0%

0.2%

c) 4-epidoxycycline≤0.5%

Not found

d) 4-epi-6-epidoxycycline≤0.5%

Not found

e) oxytetracyclie ≤0.5%

Not found

f) 2-acety-2-decarbamoyldoxycycline ADOT ≤0.5%

Not found

g) any other impurity ≤0.5%

Not found

h) not identified impurities≤0.1%

Not found

Specific Optical Rotation

-105~ -120°

-112°

Specific absorbance

At 349 nm E(1%) 300-335

323

Light absorbing impurities

At 490 nm ≤0.07

0.02

Ethanol

4.3-6.0% (m/m)

4.9%

Water

1.4-2.8%

1.9%

Sulphated ash

≤0.4%

0.1%

Assay

95.0%-102.0% (C22H25ClN2O8) based on anhydrous, ethanol-free substance

99.3%