... a plant alkaloid obtained from the Camptotheca acuminata tree), Topotecan HCl CAS #: Molecular formula:Molecular weight:Purity:119413-54 ... drug with topoisomerase I-inhibitory activity similar to irinotecan. Topotecan interferes with the growth of cancer cells, which ... replication enzymes interact with the ternary complex formed by topotecan, topoisomerase I and DNA. Mammalian cells cannot efficiently ...